Left the hostel at about 06:50 and walked the two blocks to the bus station to catch the marshrutka to Osh. I thought there might be shared taxis as well but there was only the bus. It left without being full at about 07:15. It stopped at every little village and picked up and dropped off people all along the way.
The trip took a full 9 hours but the scenery was very nice as we drove through areas of golden rolling hills and some dramatic mountains right along the highway. There were lots of sheep herds and a few herds of horses using the road as well.